Biofurries -

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BillyGoat2

True & Honest Fan
kiwifarms.net
I can only Imagine the people behind this.

Making+perfect+little+girls+in+your+basement+sounds+perfectly+normal+_4dcdf2aa1d9eac9bcabcd40beab3d37a.jpg
 

Mesosalpinx

kiwifarms.net
The amount of thought put into this is worrying. CRISPR-Cas gene replacement can be done with less than a thousand dollars in someone's garage. There are no regulations against how gene editing can be used in humans, there are only restrictions on what can be funded by the NIH. If the process is done wrong, it will create mosaics that express furry genes in the brain or lung that will kill the embryo.
 

Wallace

Cram it in me, baby!
kiwifarms.net
The amount of thought put into this is worrying. CRISPR-Cas gene replacement can be done with less than a thousand dollars in someone's garage. There are no regulations against how gene editing can be used in humans, there are only restrictions on what can be funded by the NIH. If the process is done wrong, it will create mosaics that express furry genes in the brain or lung that will kill the embryo.

tumblr_lzx43s6kiN1qdj4i3o2_r2_500.gif


We're not talking about changing one base of a well-understood gene like CTFR. I'll spare you the genetics spergery, but I assure you, this is going to remain in the realm of science fiction for the foreseeable future.
 
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Wallace

Cram it in me, baby!
kiwifarms.net
honestly this is the perfect thread for it so sperg about genetics my dude @Wallace

Right, well... You can change one base here or there if the polymorphism in question is really well-understood, sure. Of course, you need a way to get CRISPR into those cells too. Unless you're doing the experiment at the zygote stage, when a human is still just one cell, good fucking luck. That comment about "less than a thousand dollars in someone's garage" is only going to happen if you're working in something harmless like yeast.

So let's say you can do that, change a few bases in a zygote. You could conceivably fix really simple genetic problems like cystic fibrosis that way. I mean, no one has proven that it won't work. Ethical and logistical challenges not withstanding. Now you want to move onto something bigger. Say you want a more complex trait, like height. You want your baby to be the next Yao Ming. The problem is that there's not a single, binary gene that determines height. It takes hundreds, all of them working together, in interactions that we still don't fully understand yet. For something even more complex, like intelligence, that number jumps up into the thousands. Can you CRISPR that many genes all at once?

Now let's get really crazy, and try adding some new traits. Assuming we have something from another species that we can use as an analog, like animal fur, how do you introduce it? Where in the genome is it safe to jam in a few thousand bases? Additions like that can effect the expression of many other nearby genes. The number of possible interactions would make the best statisticians cry. We don't even have good tools to interrogate how this could work in a wet-bench setting.

In summary, CRSPR is not the last word in gene therapy. It's a useful tool, to be sure, but we need several more tools and a lot better understanding of how our genome operates before we're realistically ready to modify anything even close to human complexity.
 

InLivingTuna

True & Honest Fan
kiwifarms.net
This is a horrible OP and none of the further posts in the thread even explain particularly well what a biofurry is. I googled it a bit and there's no community I can find for this, so I don't think this topic's salvagable. I'm moving this thread to spergatory, @fortunecookie if you really think you could make a better thread on this topic, make it in Talk to Staff and we'll work from there.
 
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