Daraprim drug's key ingredient recreated by high school students in Sydney for just $20 -

muina

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Pyrimethamine, the active ingredient in Daraprim, treats a parasitic infection in people with weak immune systems such as pregnant women and HIV patients.

In August 2015, the price of Daraprim in the US rose from $US13.50 per tablet to $US750 when Turing Pharmaceuticals, and its controversial then-chief executive Martin Shkreli, acquired the drug's exclusive rights and hiked up the price.

Since then, the 17-year-olds from Sydney Grammar have worked in their school laboratory to create the drug cheaply in order to draw attention to its inflated price overseas, which student Milan Leonard said was "ridiculous".

"It makes sense that if you're putting billions of dollars into research for a drug like this, you should be able to reap some profit, but to do something like this … it's just not just," he said.

Milan described the moment he realised he and his classmates had been successful.

"It was ecstatic, it was bliss, it was euphoric," he said.

"After all of this time spent working and chemistry being such a high and low, after all the lows, after all the downs, being able to make this drug, it was pure bliss."

Fellow student Brandon Lee said he could not believe the result after a year of work.

"At first there was definitely disbelief," he said.

"We spent so long and there were so many obstacles that we, not lost hope, but it surprised us like 'oh, we actually made this material' and 'this can actually help people out there'.

"So it was definitely disbelief but then it turned in to happiness as we realised we finally got to our main goal
http://www.abc.net.au/news/2016-11-30/daraprim-nsw-students-create-drug-martin-shkreli-sold/8078892
 

AnOminous

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And they did how much for R&D? They waited how long with the FDA? Cost of the trials ? Cost of Marketing?

I'm sorry this is pure click bait
It's a generic drug. What R&D? It's something sold at $1 a pill in the rest of the world and $750 in the U.S. for no good reason (half that if you're a hospital because of Shkreli's "generosity").
 

Bassomatic

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It's a generic drug. What R&D? It's something sold at $1 a pill in the rest of the world and $750 in the U.S. for no good reason (half that if you're a hospital because of Shkreli's "generosity").
from the link : drug's exclusive rights

That doesn't sound generic to me. I could knock off advil for less money using wiki. That doesn't make me a hero. But maybe I should do it so I can get buzz feed to call me a good boy since big pharma is bad.

It has nothing to do with drug costs or how people feel about medical care and it's cost. This is like screwing in a light bulb and saying you're smarter than Edison.

Another tell tale is this nice little line in regards to the price hike : " it's just not just," clearly no bias at all.
 

AnOminous

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from the link : drug's exclusive rights

That doesn't sound generic to me. I could knock off advil for less money using wiki. That doesn't make me a hero. But maybe I should do it so I can get buzz feed to call me a good boy since big pharma is bad.
No, it isn't. The $1 a pill alternative is an alternative, apparently.

It has nothing to do with drug costs or how people feel about medical care and it's cost. This is like screwing in a light bulb and saying you're smarter than Edison.

Another tell tale is this nice little line in regards to the price hike : " it's just not just," clearly no bias at all.
That's a quote from the subject of the story.

I think it's pretty cool, plus the people doing it have learned chemical synthesis, which is a pretty useful skill for them and for society in general.
 

Bassomatic

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No, it isn't. The $1 a pill alternative is an alternative, apparently.



That's a quote from the subject of the story.

I think it's pretty cool, plus the people doing it have learned chemical synthesis, which is a pretty useful skill for them and for society in general.
So then why the big deal if you want to sell me advil for 9000 dollars or I can get some at walmart for 10 bucks. Why ?(esp when they love to hand generics vs brand) The drug lasted for a reason.....

I agree with the second part, it's nice kids did something useful, but it's a nuts to not see how bias it is.
 

AnOminous

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So then why the big deal if you want to sell me advil for 9000 dollars or I can get some at walmart for 10 bucks. Why ?(esp when they love to hand generics vs brand) The drug lasted for a reason.....

I agree with the second part, it's nice kids did something useful, but it's a nuts to not see how bias it is.
There's literally a million alternatives for ibuprofen.
 

Bassomatic

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There's literally a million alternatives for ibuprofen.
Exactly. So the drug price wouldn't matter. Nor would someone copying a commonly and easy to copy drug.

Again, I'm not saying it's bad these kids can into chemistry, I'm saying it's got a lot of "fuck you Martin REEEEEEE'" for no reason. If you have a problem with what he did that's fine but it's unrelated to the story.
 

AnOminous

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Exactly. So the drug price wouldn't matter. Nor would someone copying a commonly and easy to copy drug.

Again, I'm not saying it's bad these kids can into chemistry, I'm saying it's got a lot of "fuck you Martin REEEEEEE'" for no reason. If you have a problem with what he did that's fine but it's unrelated to the story.
The only reason they did it was because of Shkreli's dick move. The story would have no point at all without that. Nobody is going to bury the lead to look "fair" to a complete asshole.
 

Bassomatic

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The only reason they did it was because of Shkreli's dick move. The story would have no point at all without that. Nobody is going to bury the lead to look "fair" to a complete asshole.
Kids have a scientific break through isn't click bait enough so we should call people names is your argument. That's pretty tragic.
 
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meatslab

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Yeah I'm not seeing why this is a problem if people are able to get larger access to alternative drugs. Only one place I could find sold the pill at $1 per pill after the price hike, but they still weren't FDA approved like Shkreli's company who were the only people who distributed it to pharmacies and hospitals. They could only sell it through their own means so that means demand will be high.

Plus this means these kids took such a long time to figure this out on their own. This is a nice wholesome article and I hope these kids continue to pursue this kind of work and bring cheaper resources to everyone to come and possibly influence others on the way. News can give you warm feelings.
 

buffaloWildWings

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Part of me can't help but wonder if they did a Clock Boy Ahmed-- just bought a commercial dose of Daraprim, emptied it into an unmarked and scruffy test tube, and proudly showed it off to the adoring sensationalist media.
You can buy 50 milligram of pyrimethamine, the generic equivalent, from India for 10 cents or so.
There's also a U.S company that's selling generic 50 milligram pills for one dollar.

It's a tempest in a teapot, nothing else.
 

AnOminous

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Kids have a scientific break through isn't click bait enough so we should call people names is your argument. That's pretty tragic.
It isn't a scientific breakthrough to do a fairly simple synthesis. All it proves is that it is in fact a fairly simple synthesis, since high school kids can do it on a high school budget. It's a demonstration.

You can buy 50 milligram of pyrimethamine, the generic equivalent, from India for 10 cents or so.
There's also a U.S company that's selling generic 50 milligram pills for one dollar.
Which isn't authorized for sale by the FDA so if you're in a hospital because you need it, you're not going to be paying that. If you're paying it uninsured, you're going to be paying the rape price.
 

Bassomatic

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It isn't a scientific breakthrough to do a fairly simple synthesis. All it proves is that it is in fact a fairly simple synthesis, since high school kids can do it on a high school budget. It's a demonstration.



Which isn't authorized for sale by the FDA so if you're in a hospital because you need it, you're not going to be paying that. If you're paying it uninsured, you're going to be paying the rape price.
So then it doesn't matter at all. You are agreeing with me.

Why isn't it and only the one drug is then? Could it be maybe they DID jump through a shit ton of hoops or it works better?

I'm really trying to not be a dick to you, but it's unrelated completely to the link and a hit piece. I can't see why you are focusing on it as well.
 

Jon-Kacho

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Cool. Now spend years on R&D making a brand new drug from scratch, put it through years of clinical trials, pour billions of dollars into it, and then give it away for next to nothing because "it's just not just" to recuperate your costs.
 

Gym Leader Elesa

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Cool. Now spend years on R&D making a brand new drug from scratch, put it through years of clinical trials, pour billions of dollars into it, and then give it away for next to nothing because "it's just not just" to recuperate your costs.
> implying the original hadn't already recouped it's costs ten times over and there was any reason besides sadism and misanthropy to hike the price

But that said I agree, otherwise. It's an amusing article, but unfortunately, it helps no one. Good on those kids for giving a shit to at least try to learn something useful.
 

DuskEngine

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Cool. Now spend years on R&D making a brand new drug from scratch, put it through years of clinical trials, pour billions of dollars into it, and then give it away for next to nothing because "it's just not just" to recuperate your costs.
Pyrimethamine was developed in 1953 and most "R&D" costs that pharmaceutical companies incur are just for tweaking the formula around enough that they can evergreen them.
 
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Gym Leader Elesa

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Do you have the accounting to prove that?
Indeed, no. Not directly.

It was the consensus of many as Shrekli freely admitted he hiked the price because he believed it to be too low, and for no other reason, given the value of the drug to its patients, but when purchased it had been selling at around $13.50 since 1953.

"You only need less than 100 pills so at the end of the day, the price for treatment – to save your life – was only $1,000," Shkreli told Bloomberg TV on Sept. 21, 2015. "These days, in modern pharmaceuticals, cancer drugs can cost $100,000 or more, rare disease drugs can cost half a million dollars. Daraprim is still underpriced, relative to its peers."
Actually one of Mr.Shrekli's more charitable quotes on the matter. Generally his statements could be paraphrased as "I know people need it, but I could be a lot richer, still."

Simply put, cancer and rare disease drugs are almost always under patent, while Daraprim’s expired in 1953. And unlike Daraprim, those drugs are the products of expensive, recent research.

"The comparison is irrelevant. Cancer drugs were developed by companies that invested hundreds of millions of dollars, billions of dollars in research and development," said John Lamattina, a former senior vice president at pharmaceutical giant Pfizer Inc., who currently writes about the industry for Forbes.

Daraprim, meanwhile, "is generic drug. There’s no research and development they had to do," said Gerard Anderson, a professor of health economics and finance at Johns Hopkins University.
Source:

http://www.politifact.com/punditfact/statements/2015/sep/24/martin-shkreli/fact-checking-martin-shkrelis-claim-daraprim-under/

His only motive is greed, and this is well-established. There aren't even costs for him to recoup. There's no socialist feel-good propaganda here, the man is simply what happens when an otherwise good capitalist system is abused. I admit I should have been more reserved in my condemnation earlier, however. Excessive greed doesn't necessarily equal sadism and misanthropy, it just almost always does.
 
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