If Brian O'Halloran is going to be in it, might as well guarantee that the audience will never feel bad for the main characters by having Kevin Smith direct it.
If Kevin Smith directs it the movie will have too many changes that just wouldn't work. It would be needlessly more disgusting than Phil already is, Phil would use all of his words and phrases correctly (which would make the whole thing less funny) and instead of the cast we want we'll get the same people Smith uses in every movie. We'd also get tons of needless, gross sex references and an impossible happy ending.
I'm still on board with Harmony Korine directing, though. We would at least get a really trippy version of him in the hospital with Leanna.