Generally yes. I didn't think we were debating that? I just find this artist to have some good illustrated points in a few of their comics about troons. Even though a lot of redfems are batty with some of their views.
I would guess that it's taken at AGDQ 2013. On the left is Cosmo, above him is his womansona Narcissa. One year later at AGDQ something happened that broke his brain. While speedrunning Zelda or something his longtime girlfriend decided to become polyamorous with the other nerds and his internet friends. It's my suspicion that this sent him down the path of becoming his own perfect woman.
Thumbnail of people describing what was going on, it's mainly about another streamers girlfriend. Big picture so click the arrow in the top right to have it open full size in another window(or right click - view image in firefox or open image in new tab in chrome).
Short version from reddit. There's a thread on the guy here as well that have more info on everything.