The OP or the title of this thread should mention that Kanye West is bipolar.
In a 2019 interview in Vogue magazine, (Kim) Kardashian-West openly discussed her husband's mental health issues. She said that, in the past, West found it hard to accept that he has bipolar disorder, telling people that he was instead suffering from sleep deprivation. However, she said that he now accepts his diagnosis. "'I think we're in a pretty good place with it now,' she said, adding that West has a newfound sense of purpose -- to show that you can live a normal life with mental illness. 'It is an emotional process, for sure. Right now everything is really calm. But we can definitely feel episodes coming, and we know how to handle them.'"
But for West, "handling them" doesn't include medications. According to Kardashian-West, "For him, being on medication is not really an option, because it just changes who he is."