When we rejoin the story, Darlene and David – played by Sara Gilbert and Big Bang Theory star Johnny Galecki – have had a son and a daughter.
And according to Showbiz 411, the couple’s son, nine-year-old Mark, will be “gender creative.”
The showrunners’ casting call is requesting children who can play a “sensitive and effeminate” part which “displays qualities of both young female and male traits.”
The show has taken controversial moves to include LGBT content before, having featured a lesbian kiss in a 1994 episode called Don’t Ask, Don’t Tell.
Roseanne will return – with its original cast, including John Goodman and Sarah Chalke – in 2018.