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Kiwi Farms
Manga tends to be batshit - let's talk about it. Can be anything - a cover, a panel, pages, dialogue, themes etc.
I'll start with something that isn't to do with Junji Ito. I find stitches being used in ways that violate the body unnerving, so when a particular double spread from Franken Fran showed up my stomach churned in disgust: