But Chris always leaves an out for himself (Not that it ever works), it’s an open marriage.The polyamorous marriage facade would have to cease completely, it's very much wound up in his identity and personal beliefs that he can have relationships with these characters that simply don't exist to us, but to him they are believable enough to be real, regardless about how hard he wants da marge to be real and wishes all his problems away.
Something would have to break him hard enough to simply realise that no one is going to protect his backside anymore, whether that is actually him seeing Barb dead one morning, or he gets evicted out of the home with absolutely no help on the horizon (personally I want to see this rude awakening happen because I think he needs a good slap across the face that he's a complete failure and wasted his life away, but I digress) only then would his attachment on his delusions weaken, because at that point, they're useless to him at that point, and if he genuinely is not retarded and dumb as he makes himself out to be, he may attempt to turn his life in the partially right direction.
Unless a white knight or enabler coddles him and keeps him wrapped in cotton wool for longer, but that will do more harm then good in the long term I think.