Keeper of the Light from Dota 2, the picture itself is from the meme above. His abbreviation is Kotl but russians pronounce or sometimes write it "Kotol"
WCW wrestler The Renegade. In a brilliantly Carny move, Hulk Hogan teased we would see "the ultimate surprise", which turned out to be a former bodybuilder who aped the look and mannerisms of The Ultimate Warrior. Not a funny ending though, as the gimmick bombed and he killed himself after being released.
Raleigh from Lost at Sea. (Bryan Lee O Malley of Scott Pilgrim fames first book)
Specifically at this moment in the book that is my profile pic, she's in a motel with some people she just met and has these visions of cats on the side of her bed, shes allergic to them, and she's wigging the fuck out and cant sleep because of it.
Poe the sheep from the popular early internet screen mate known commonly as scmpoo, released in 1995 and came from the realm of Japan, as the character is based off a show.
Yotsuba from Yotsuba&!. (Or Yotsubato in Japan) Some of you may recognize her as the 404 girl from 4Chan.
Despite what the avatar may suggest, it's actually a very sweet and wholesome series and the chapter it's from is simply about her pretending to kill people with a water gun.