Old Man Coyote from Crow mythology. He's portrayed as having a massive penis that he frequently causes trouble with. In one story, his anus becomes a home for ducks. It's so batshit insane, I can't help but love it.
Medusa. Her story is so incredibly tragic. She gets turned into a hideous monster for the rest of her life (which ends abruptly because some dude needs the power of her hideousness to kill something so he cuts her fucking head off.) All for the terrible crime of being raped by a god. But is that injustice what she's famous for? No. She's famous for being hideous. The tribulations of Job ain't got nothing on that bitch.