Wuhan Coronavirus - COVID-19 Analysis & Summary - This is not just fucking pneumonia. It is everything but the kitchen sink. Lungs, heart, kidneys, liver, brain, blood vessels, testes. It affects them all.

  • Downtime due to DDoS attacks still. I'm waiting on different providers to give me what I need to deal with it long-term.

Drain Todger

Unhinged Doomsayer
True & Honest Fan
kiwifarms.net
OP's Dox
SUMMARY OF SARS-CoV/SARS-CoV-2 AND COVID-19 FINDINGS

SECTION I: Overview

Current COVID-19 tracking services:


Johns Hopkins

New York Times (NYT)

Worldometer

Evaluation of current therapies:

Chloroquine: Showing the most promise

Hydroxychloroquine: Effective, but many side effects including prolonged QTC interval possibly dangerous in patients with hypertension and low ejection fractions.

Remdesivir: Currently undergoing trials

Tocilizumab: Currently undergoing trials

Convalescent Plasma: determined to be a promising treatment, however the supply of plasma as the ratio of cured individuals to sick patients is extremely low. Convalescent plasma therapy is a labor-intensive therapy, and in a time of pandemic, may not be the most economically viable treatment available. This type of therapy is widely known to be effective.

Note: All dates on all linked articles are in ISO YYYY-MM-DD format. All articles are to be sorted by oldest-first and formatted with the title in italics, date in bold with parentheses, and URL in brackets.[/SPOILER]

SECTION II: Pathology

Section II-A: Transmission & Strains

There is a lot of conflicting information on R0 values for COVID-19.
In one epidemiological study, the disease was estimated to have a peak R0, the reproduction value, of around 6.6, which means 1 person infects that many other people, on average. One Belgian scientist said it was between 4.7 to 7. In various other locations and studies, the R0 was calculated at around 2 to 3, largely because of differences in population density and public transport use. In other words, the R0 has been variously calculated as being somewhere between 2 and 7. In some locales, the R0 may vary depending on human behavior. There are also super-spreader incidents where one person can infect dozens of others:

The Novel Coronavirus, 2019-nCoV, is Highly Contagious and More Infectious Than Initially Estimated (2020-02-11) [https://www.medrxiv.org/content/10.1101/2020.02.07.20021154v1]

Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) (2020-02-16 to 2020-02-24) [https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf]

Open letter to the Minister of Public Health: "Coronavirus, you have to know how to listen to fear" (2020-02-28 ) [https://www.rtbf.be/info/opinions/detail_lettre-ouverte-a-la-ministre-de-la-sante-publique-coronavirus-il-faut-savoir-ecouter-la-peur?id=10443799]

The median incubation period is around 5 days, but rare outliers of 24+ days have been seen:

Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study (2020-02-20) [https://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30026-1/fulltext]

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application (2020-03-10) [https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported]

SARS-CoV-2 is apparently airborne and can linger in aerosols for a very long time. One study in China indicated that the virus could travel as far as 4.5 meters/15 feet, rendering the CDC’s 6-foot gap provision insufficient:

China confirms aerosol spread of Covid-19, frontline medical workers need to wear right masks (2020-02-24) [https://www.msn.com/en-sg/news/world/china-confirms-aerosol-spread-of-covid-19-frontline-medical-workers-need-to-wear-right-masks/ar-BB10ljdt?ocid=ems.msn.dl.RosetteNebula]

Transmission routes of 2019-nCoV and controls in dental practice (2020-03-03) [https://www.nature.com/articles/s41368-020-0075-9]

Coronavirus can travel twice as far as official ‘safe distance’ and stay in air for 30 minutes, Chinese study finds (2020-03-09) [https://www.scmp.com/news/china/science/article/3074351/coronavirus-can-travel-twice-far-official-safe-distance-and-stay]

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 (2020-03-17) [https://www.nejm.org/doi/full/10.1056/NEJMc2004973]

Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19) in Healthcare Settings (2020-03-19) [https://www.cdc.gov/coronavirus/2019-ncov/infection-control/control-recommendations.html]

SARS-CoV-2 RNA was detectable on the Diamond Princess for 17 days. However, these could be non-viable fragments of virions:

CDC says coronavirus RNA found in Princess Cruise ship cabins up to 17 days after passengers left (2020-03-23) [https://www.cnbc.com/2020/03/23/cdc-coronavirus-survived-in-princess-cruise-cabins-up-to-17-days-after-passengers-left.html]

Expert reaction to CDC report on COVID-19 outbreaks on cruise ships, which includes that SARS-CoV-2 RNA was identified on surfaces in cabins up to 17 days after they were vacated (2020-03-24) [https://www.sciencemediacentre.org/expert-reaction-to-cdc-report-on-covid-19-outbreaks-on-cruise-ships-which-includes-that-sars-cov-2-rna-was-identified-on-surfaces-in-cabins-up-to-17-days-after-they-were-vacated/]

SARS-CoV is known to have spread by the oral-fecal route and through airborne sewage particulate matter, and SARS-CoV-2 is likely no different in that regard. SARS causes enteric symptoms and contaminates sewers and makes them hazardous:

Pathogen cross-transmission via building sanitary plumbing systems in a full scale pilot test-rig (2017-02-10) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302810/]

COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission (2020-02-26) [https://www.gastrojournal.org/article/S0016-5085(20)30281-X/pdf]

Gastrointestinal Symptoms Could Be New Focus for Coronavirus Diagnosis (2020-03-09) [https://www.contagionlive.com/news/gastrointestinal-symptoms-could-be-new-focus-for-coronavirus-diagnosis-]

Guidance for Kansas Drinking Water and Wastewater (2020-03-12) [http://www.kdheks.gov/coronavirus/toolkit/COVID-19_Water_and_Wastewater_Guidance.pdf]

Stomach Ache And Diarrhea May Be Among The First Signs Of COVID-19 Coronavirus (2020-03-20) [https://www.forbes.com/sites/robertglatter/2020/03/20/stomach-ache-and-diarrhea-may-be-some-of-the-first-signs-of-covid-19-coronavirus/]

SARS-CoV-2 is capable of asymptomatic transmission and it is practically impossible to stop the spread by contact tracing and minor quarantines. There are a multitude of asymptomatic carriers walking around:

Asymptomatic cases in a family cluster with SARS-CoV-2 infection (2020-02-19) [https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30114-6/fulltext]

Potential Transmission of SARS-CoV-2 from an Asymptomatic Carrier (2020-02-24) [https://www.jwatch.org/na50998/2020/02/24/potential-transmission-sars-cov-2-asymptomatic-carrier]

Potential Presymptomatic Transmission of SARS-CoV-2, Zhejiang Province, China, 2020 (2020-03-09) [https://wwwnc.cdc.gov/eid/article/26/5/20-0198_article]

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients (2020-03-19) [https://www.nejm.org/doi/full/10.1056/NEJMc2001737]

SARS-CoV-2 can enter the eye through the ocular surface. Any protective mask must be full-face. Half-face masks are insufficient. Conjunctivitis can be a sign of infection:

2019-nCoV transmission through the ocular surface must not be ignored (2020-02-06) [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30313-5/fulltext]

Coronavirus Eye Safety (2020-03-10) [https://www.aao.org/eye-health/tips-prevention/coronavirus-covid19-eye-infection-pinkeye]

There is conflicting evidence that the virus may be a possible recombinant chimera:

Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020-01-29) [https://www.sciencedirect.com/science/article/pii/S1567134820300447]

Coronavirus Could Be a 'Chimera' of Two Different Viruses, Genome Analysis Suggests (2020-03-24) [https://www.sciencealert.com/genome-analysis-of-the-coronavirus-suggests-two-viruses-may-have-combined]

There are now two recognized strains of the disease. The L strain is more infectious and severe than the ancestral S strain:

On the origin and continuing evolution of SARS-CoV-2 (2020-03-03) [https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwaa036/5775463]

Coronavirus: aggressive ‘L type’ strain affecting 70 per cent of cases (2020-03-06) [https://www.sciencefocus.com/news/coronavirus-aggressive-l-type-strain-affecting-70-per-cent-of-cases/]

How fast can the coronavirus mutate? (2020-03-09) [https://www.livescience.com/coronavirus-mutations.html]

SARS-CoV and SARS-CoV-2 are around 80% genetically similar and may have a few shared pathological factors:

Severe acute respiratory syndrome coronavirus 2 isolate 2019-nCoV WHU01, complete genome (2020-01-02) [https://www.ncbi.nlm.nih.gov/nuccore/MN988668]

Virologists Find Coronavirus Is 80% The Same as SARS, Which May Help Us Neutralise It (2020-02-04) [https://www.sciencealert.com/genetic-analysis-shows-wuhan-coronavirus-is-similar-to-sars]

What We Know Today about Coronavirus SARS-CoV-2 and Where Do We Go from Here (2020-02-19) [https://www.genengnews.com/insights/what-we-know-today-about-coronavirus-sars-cov-2-and-where-do-we-go-from-here/]

Section II-B: Cellular Entry

The virus binds to ACE2 receptors in human cells.
ACE2 receptors are found in many vital organs and reproductive tissues in the human body. Lungs, heart, kidneys, brain. SARS-CoV-2 infection may also have negative effects on male fertility. ACE2 receptors are found in the seminiferous ducts of the testis:

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004-05-07) [https://onlinelibrary.wiley.com/doi/full/10.1002/path.1570]

ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia (2020-11-10) https://jvi.asm.org/content/79/23/14614

Angiotensin converting enzyme 2 in the brain (2008-11-05) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667944/]

ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection (2020-02-13) [https://www.medrxiv.org/content/10.1101/2020.02.12.20022418v1]

scRNA-seq Profiling of Human Testes Reveals the Presence of ACE2 Receptor, a Target for SARS-CoV-2 Infection, in Spermatogonia, Leydig and Sertoli Cells (2020-02-18 ) [https://www.preprints.org/manuscript/202002.0299/v1]

The Cardiac Implications of Novel Coronavirus (2020-02-20) [https://www.dicardiology.com/article/cardiac-implications-novel-coronavirus]

ACE2 Is the SARS-CoV-2 Receptor Required for Cell Entry (2020-03-18 ) [https://www.jwatch.org/na51115/2020/03/18/ace2-sars-cov-2-receptor-required-cell-entry]

When the virus binds to ACE2 receptors, it blocks off the ACE2 receptors and leaves excess circulating Angiotensin II (normally, Ang II uses ACE2 to convert into Ang 1-7, a MasR agonist). This goes on to cause inflammation and possibly even hypertension and/or electrolyte imbalance:

Renin–angiotensin system in human coronavirus pathogenesis (2010-03-01) [https://www.futuremedicine.com/doi/10.2217/fvl.10.4]

Pathology and Pathogenesis of Severe Acute Respiratory Syndrome (2010-12-16) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829448/]

Response to the emerging novel coronavirus outbreak (2020-01-31) [https://www.bmj.com/content/368/bmj.m406/rr-15]

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target (2020-03-03) [https://link.springer.com/article/10.1007/s00134-020-05985-9]

SARS-CoV has been shown to be capable of Dengue-like antibody-dependent enhancement, tricking the immune system into aiding the virus. It is unknown whether or not SARS-CoV-2 can do the same:

Investigation of Antibody-Dependent Enhancement (ADE) of SARS coronavirus infection and its role in pathogenesis of SARS (2011-01-10) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019510/]

Molecular Mechanism for Antibody-Dependent Enhancement (2019-12-11) [https://www.msi.umn.edu/~lifang/flpapers/fang_li_mers_ade_jvi_2019.pdf]

Is COVID-19 receiving ADE from other coronaviruses? (2020-02-13) https://www.sciencedirect.com/science/article/pii/S1286457920300344?via%3Dihub

Medical Countermeasures Analysis of 2019-nCoV and Vaccine Risks for Antibody-Dependent Enhancement (ADE) (2020-03-08 ) [https://www.preprints.org/manuscript/202003.0138/v1]

SARS-CoV-2 has a furin cleavage site on the spike glycoprotein that may greatly enhance cell-to-cell fusion and infectiousness:

Furin cleavage site in the SARS-CoV-2 coronavirus glycoprotein (2020-02-13) [http://www.virology.ws/2020/02/13/furin-cleavage-site-in-the-sars-cov-2-coronavirus-glycoprotein/]

The Proximal Origin of SARS-CoV-2 (2020-02-16) http://virological.org/t/the-proximal-origin-of-sars-cov-2/398

Coronavirus far more likely than Sars to bond to human cells due to HIV-like mutation, scientists say (2020-02-27) [https://www.scmp.com/news/china/society/article/3052495/coronavirus-far-more-likely-sars-bond-human-cells-scientists-say]

Why does SARS-CoV-2 spread so easily? (2020-03-17) [https://www.medicalnewstoday.com/articles/why-does-sars-cov-2-spread-so-easily]

Angiotensin blockers (ARBs), like Losartan and Telmisartan may have unwanted side effects, like increasing the number of host cell receptors that the virus can use. Generally, patients treated with ARBs have higher concentrations of ACE2 receptors on pulmonary, etc. Epithelial cells, increasing the efficacy of host cell binding. Some conflicting information indicates that they may also block the effects of the virus, leaving open the possibility of their use in therapy. Whether or not ARBs are safe to use on COVID-19 patients remains a matter of some dispute:

Response to the emerging novel coronavirus outbreak (2020-01-31) [https://www.bmj.com/content/368/bmj.m406/rr-2]

Inhibitors of RAS Might Be a Good Choice for the Therapy of COVID-19 Pneumonia (2020-02-16) [https://www.ncbi.nlm.nih.gov/pubmed/32061198]

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? (2020-03-11) [https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext]

ACE inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19, paper suggests (2020-03-23) [https://www.sciencedaily.com/releases/2020/03/200323101354.htm]

Section II-C: Pulmonary Signs

The primary pathology of note in COVID-19 is bilateral pneumonia with ground-glass lesions visible in CT scans:


Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study (2020-02-24) [https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30086-4/fulltext]

A Medical Worker Describes Terrifying Lung Failure From COVID-19 — Even in His Young Patients (2020-03-21) [https://www.propublica.org/article/a-medical-worker-describes--terrifying-lung-failure-from-covid19-even-in-his-young-patients]

SARS-CoV-2 can potentially cause irreversible lung fibrosis and chronic lung disease if not caught and treated with antivirals at an early stage. This has serious implications for treatment of recovered patients who subsequently get infected with a different strain; their weakened condition may increase mortality. One COVID-19 victim had such severe damage to their lungs, they needed to be treated with a double lung transplant:

Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19) (2020-02-26) [https://www.preprints.org/manuscript/202002.0407/v3/download]

Autopsies offer key clues for early stage COVID-19 patients (2020-02-29) [https://www.globaltimes.cn/content/1181121.shtml]

China's Zhejiang completes lung transplant for COVID-19 patient (2020-03-02) [http://www.xinhuanet.com/english/2020-03/02/c_138836428.htm]

Chinese doctors say coronavirus ‘like a combination of SARS and AIDS’, can cause irreversible lung damage (2020-03-05) [https://www.news.com.au/lifestyle/health/health-problems/chinese-doctors-say-coronavirus-like-a-combination-of-sars-and-aids-can-cause-irreversible-lung-damage/news-story/f58f19c5eeae99b845c54e2d2b9305ca]

Section II-D: Cardiovascular Signs

SARS-CoV-2 can potentially cause myocarditis leading to myoglobin accumulation in the blood, cardiomyopathy, and cardiac or renal failure.
Some contradictory studies indicate heart tissue remains mostly normal under histopathological examination, while others indicate severe myocarditis:

Here’s What Happens to the Body After Contracting the Coronavirus (2020-02-20) [https://www.healthline.com/health-news/heres-what-happens-to-the-body-after-contracting-the-coronavirus#Liver-and-kidneys]

COVID-19 Clinical Guidance For the Cardiovascular Care Team (2020-03-06) [https://www.acc.org/~/media/665AFA1E710B4B3293138D14BE8D1213.pdf]

First Case of COVID-19 Infection with Fulminant Myocarditis Complication: Case Report and Insights (2020-03-10) [https://www.preprints.org/manuscript/202003.0180/v1]

SARS-CoV has been known to cause vasculitis of the organs, possibly by attacking blood vessels directly. It is unknown whether or not this also applies to SARS-CoV-2. Substantially more research is needed on this topic:

Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection (2007-10-12) [https://cmr.asm.org/content/20/4/660]

Section II-E: Neurological Signs

SARS-CoV (a relative of SARS-CoV-2) has been shown to cause neural death (surprisingly without encephalitis) in transgenic mouse models.
Recent, concerning reports of anosmia in COVID-19 patients may perhaps indicate olfactory nerve infiltration or inflammation of the surrounding tissues; this needs investigation:

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 (2008-05-21) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493326/]

If you've lost your sense of smell or taste, you could be a 'hidden carrier' of the coronavirus (2020-03-22) [https://www.businessinsider.com/coronavirus-symptoms-loss-of-smell-taste-covid-19-anosmia-hyposmia-2020-3]

SARS-CoV was also found in the brains of infected patients in previous outbreaks:

New Study Shows SARS Can Infect Brain Tissue (2005-09-15) [https://www.sciencedaily.com/releases/2005/09/050915002938.htm]

Neurological manifestations in severe acute respiratory syndrome. (2005-10-29) [https://www.ncbi.nlm.nih.gov/pubmed/16252612]

Angiotensin converting enzyme 2 in the brain (2009-04-12) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667944/

Recent information seems to suggest that SARS-CoV-2 can cause neurological symptoms and cerebrovascular disease, leading to loss of autonomic functions of the brain and, in the worst case, lingering brain damage. The virus can apparently attack the medulla or even cause viral encephalitis, and some patients have had the virus found in their cerebrospinal fluid:

The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients (2020-02-24) [https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25728]

Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study (2020-02-25) [https://www.medrxiv.org/content/10.1101/2020.02.22.20026500v1]

Beijing hospital confirms nervous system infections by novel coronavirus (2020-03-05) [http://www.xinhuanet.com/english/2020-03/05/c_138846529.htm]

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms (2020-03-13) [https://pubs.acs.org/doi/10.1021/acschemneuro.0c00122]

Section II-F: Renal Signs

COVID-19 can cause acute kidney injury, and can be a serious threat to those with pre-existing kidney disease:


COVID-19: challenges for renal services (2020-03-11) [https://renal.org/covid-19/ra-resources-renal-professionals/covid-19-challenges-renal-services/]

Kidney disease is associated with in-hospital death of patients with COVID-19 (2020-03-16) [https://www.kidney-international.org/article/S0085-2538(20)30255-6/fulltext#sec1.3]

Section II-G: Hepatic Signs

Patients with severe COVID-19 were known to have notable changes to their liver function:


Liver injury in COVID-19: management and challenges (2020-03-04) [https://www.thelancet.com/journals/langas/article/PIIS2468-1253(20)30057-1/fulltext]

Section II-H: Gastrointestinal Signs

COVID-19 patients with digestive symptoms have worse clinical outcomes:


The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes (2020-01-31) [https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1]

About Half of COVID-19 Cases Show Digestive Signs (2020-03-19) [https://www.webmd.com/lung/news/20200319/about-half-of-covid-cases-show-digestive-signs]

COVID-19 can also possibly cause massive co-infections of prevotella, a normally harmless gut bacteria, potentially even displaying bacteriophage-like synergistic behavior with prevotella. The researchers seemed to have low confidence in this result, but it may be something worth following up on to see if SARS-CoV-2 is capable of bacteriophage-like behavior in vitro. Bacteriophage-like behavior, if present, could make the virus into a persistent environmental contaminant, and would have serious implications vis a vis disposal of bodies of COVID-19 victims and treatment of wastewater. However, the idea of a virus that infects both prokaryotic and eukaryotic cells is very strange:

The 2019 Wuhan outbreak could be caused by the bacteria Prevotella, which is aided by the coronavirus - Prevotella is present (sometimes in hugea mounts) in patients from two studies in China and one in Hong Kong (2020-02-03) [https://osf.io/usztn/]

Sequencing data (N=3) shows Wuhan coronavirus integration in bacteria (Prevotella mostly). Sequencing artifact - or is the virus infecting both bacterial and human cells? (2020-02-04) [https://osf.io/ktngw/]

Section II-I: Immunological Signs

SARS-CoV and SARS-CoV-2 can both cause cytokine storms, where inflammatory agents released by the body's own immune system begin to over-accumulate and damage tissues that they were sent to protect:


Into the Eye of the Cytokine Storm (2012-03-05) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294426/]

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020-01-24) [https://www.thelancet.com/action/showPdf?pii=S0140-6736(20)30183-5]

Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020-02-18 ) [https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30076-X/fulltext]
 

Drain Todger

Unhinged Doomsayer
True & Honest Fan
kiwifarms.net
SECTION III: Potential Drugs and Therapies

Remdesivir and Chloroquine show promise in inhibiting viral replication:

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020-02-18 )[https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_article]

Gilead Sciences Update On The Company’s Ongoing Response To COVID-19 (2020-03-22) [https://www.gilead.com/purpose/advancing-global-health/covid-19]

Hydroxychloroquine Use For COVID-19 Coronavirus Shows No Benefit In First Small—But Limited—Controlled Trial (2020-03-25) [https://www.forbes.com/sites/tarahaelle/2020/03/25/chloroquine-use-for-covid-19-shows-no-benefit-in-first-small-but-limited-controlled-trial/#6fedc7fc4c86]

Did chloroquine really fail a COVID-19 study—or was the trial design to blame? (2020-03-26) [https://www.fiercepharma.com/pharma-asia/did-chloroquine-really-fail-a-covid-19-study-or-was-it-just-trial-design-s-fault]

CytoSorb, an extracorporeal filtration therapy, may help with cytokine release syndrome (a.k.a cytokine storm):

CYTOSORB, THE WUHAN CORONAVIRUS, AND CYTOKINE STORM (2020-01-28 ) [https://cytosorbents.com/cytosorb-the-wuhan-coronavirus-and-cytokine-storm/]

CytoSorb Shipment Arrives in Designated Mainland China Hospitals to Treat Cytokine Storm in Critically-ill Patients with COVID-19 Coronavirus Infection (2020-02-28 )[http://cytosorbents.mediaroom.com/2020-02-28-CytoSorb-Shipment-Arrives-in-Designated-Mainland-China-Hospitals-to-Treat-Cytokine-Storm-in-Critically-ill-Patients-with-COVID-19-Coronavirus-Infection]

CytoSorbents Provides Update on CytoSorb and COVID-19 Coronavirus Activities (2020-03-12) [https://www.biospace.com/article/releases/cytosorbents-provides-update-on-cytosorb-and-covid-19-coronavirus-activities/]

The virus is reliant on TMPRSS2 and certain protease inhibitors may be able to block the virus from fusing with cells:

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor (2020-03-05) [https://www.cell.com/cell/fulltext/S0092-8674(20)30229-4?rss=yes]

Novel antiviral proteins like DRACO could be used to stop pandemics in their tracks even without a vaccine available. Continued development of this technology could be used in the future to block pandemic spread entirely:

DRACO Broad-Spectrum Antiviral Therapeutics (Date N/A) [https://riderinstitute.org/discovery/]

Broad-Spectrum Antiviral Therapeutics (2011-07-27) [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022572]

Draper Nanotechnology Could Fight Influenza, Other Viruses (2014-01-06) [https://www.draper.com/news-releases/draper-nanotechnology-could-fight-influenza-other-viruses]

SECTION IV: Summary & PPE/Disinfection Notes

Quick Summary:
  • Extremely contagious.
  • Long incubation period with asymptomatic transmission.
  • Very high likelihood of airborne aerosol transmission as well as oral-fecal transmission.
  • Causes severe bilateral viral pneumonia with ground-glass opacities in the lungs visible on CT.
  • Can cause irreversible lung fibrosis and loss of oxygen exchange capacity in the lungs.
  • Can potentially cause myocarditis and subsequent myoglobinemia that shuts down the kidneys due to myoglobin entering the blood from the damaged heart.
  • Can cause cytokine release syndrome and inflammation profound enough to damage vital organs.
  • Can potentially damage blood vessels with vasculitis especially inside certain vital organs.
  • Can potentially damage blood vessels and/or neurons in the brain (which may be the cause for the mysterious sudden drop fatalities with people suffering apparent brain death and seizures, as seen in leaked social media footage). Could cause persistent brain damage, brain stem injury, diaphragm paralysis, seizures, and possibly even a persistent vegetative state due to its neuroinvasive potential.
  • Can cause bacterial co-infections.
  • Can suppress the immune system so badly that ordinary gut bacteria start causing bacterial co-infections, potentially even causing GI tract symptoms.
Necessary PPE/Protective Measures:
  • Full-face P100 or Full-face 40mm NATO CBRN respirator or hood unit with a PAPR necessary
  • Skin-tight goggles and a half-face P100 may be used if nothing else is available (full-face respirator or hood preferable)
  • Disposable overalls and boot covers (Tyvek or Tychem)
  • Nitrile Gloves (8-mil or double-gloved 4-mil)
  • Chemtape (to seal wrists and other gaps)
  • Decontamination of all gear with peroxide coupled with proper doffing technique, followed by thorough hand-washing and showering
Inadequate PPE/Protective Measures
  • N95 half-face respirators or surgical masks (the virus can enter the eyes and is small enough to pass through N95 filter media, and loose-fitting surgical masks provide no protection at all; they only help trap your own droplets or aerosols if you’re already sick; N95s are certainly better than nothing, however)
  • Face shield (the virus droplets or aerosols can go around the shield and enter the eyes)
  • Nitrile gloves alone (most infections are from droplets or aerosols, not touching fomites)
  • Hand-washing alone, with no PPE (see above)
Disinfection Measures:
  • Coronaviruses are fairly fragile. Bleach, ammonia, and peroxide all work against them, but I personally recommend Diversey Oxivir or a similar peroxide solution, placed in a spray bottle or garden sprayer, combined with UV light (through the use of a stationary lamp or handheld wand) to disinfect objects. Avoid using UV on skin or rubber (like gas mask seals), as it ages and damages them the same as sun exposure.
  • Great care must be taken when donning and doffing gear. All gear must be sprayed down with disinfectant, preferably aqueous peroxide solution—especially on the touch surfaces and the ends of any respirator filters—before being removed.
  • Tainted water should not be ingested. Tap water must be treated and chlorinated to prevent contamination. In locales where tap water cannot be treated properly, it may be necessary to distill water or collect rainwater for drinking.
  • Standard SOP for BSL-2 labs (and above) generally indicate that 10% sodium hypochlorite (1:10 bleach) followed by 70% EToH is most effective for maintaining a sterile surface.
Please see the following for EPA-approved disinfectants for use against SARS-CoV-2:

List N: Disinfectants for Use Against SARS-CoV-2 (Continually Updated) [https://www.epa.gov/pesticide-registration/list-n-disinfectants-use-against-sars-cov-2]

SECTION V: Statement

COVID-19 is a deceptive and sinister disease that outwardly presents as severe pneumonia while stealthily causing damage to many of its victims’ vital organs. The disease may spread by aerosol or droplet transmission, fomite-to-face, or the oral-fecal route. The human waste of COVID-19 victims contaminates sewers, potentially infecting other people.

There is no immunity in the general population to these viruses, and anyone can become sickened. TH2 vaccines for SARS-CoV have failed in animal tests in the past because they caused abnormal cytokine responses and lung lesions (T-helper immunopathology). In 17 years, no one has successfully discovered a safe and viable SARS-CoV vaccine, and it is unknown whether or not the same vaccine development difficulties also apply to SARS-CoV-2.

Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. (2012-04-20) [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421]

This virus is a serious threat to the lives of people across the globe, and a national security threat beyond compare. We are all in grave danger with something like this on the loose. I implore the authorities to coordinate with virologists, epidemiologists, and critical care experts to come up with a plan of action. If this virus explodes in a major metropolitan area, you could see many thousands of terribly sick people swarming into hospitals and overflowing their surge capacity. The window of opportunity to prevent possibly millions of excess deaths is rapidly closing.

We should have had negative-pressure tent cities capable of treating tens of thousands of people established and staged outside major metropolitan areas at the beginning of February, in anticipation of pandemic spread. We need more oxygen concentrators and ventilators for the sick. If one is in a position to do so, they should investigate possible avenues of research and treatments, as listed above.

Of the known cases of COVID-19, 80% are mild, but 20% are severe or critical, quickly overwhelming the available numbers of ICU beds, ventilators, and other critical care resources.

This illness, if left unchecked, could kill many tens of millions of people globally and severely damage the quality of life of billions more. There is an urgent need for money and resources to combat COVID-19.

We are now in a state of war against a lethal pandemic disease.

The key takeaway — SARS-CoV-2 does not only cause pneumonia.

It can also cause irreversible lung fibrosis, myocarditis, acute kidney injury, viral hepatitis, severe bacterial co-infections, autoimmune reactions (cytokine release syndrome), and cerebrovascular and/or medullary issues, as mentioned previously. Many of these things may lead to chronic, lifelong illness, such as the kind experienced by SARS survivors. Mental issues, chronic fatigue, and joint issues from methylprednisolone treatment were common with SARS patients. Many suspected COVID-19 sufferers have been witnessed across the globe collapsing and suffering seizures, abnormal posturing, the fencing response, and so on, indicative of serious brain damage and neurotropism of the virus. These disturbing complications demand further investigation.

The reason why this is a problem is because it means that the CDC’s guidelines for healthcare workers are inadequate:

Information for Healthcare Professionals (2020-03-20) [https://www.cdc.gov/coronavirus/2019-ncov/hcp/index.html]

These guidelines present COVID-19 mainly as a lower respiratory disease and recommend that deceased COVID-19 victims have their lungs sectioned and examined for histopathological changes. However, if the disease can also renal, hepatic, cardiac, and neurological changes, then it may also be necessary to section and examine those tissues as well. The risks for coroners performing this work are severe. COVID-19 is highly infectious; removing the tissues for examination requires a lot of quality PPE and observation of biosafety protocols.

Again, COVID-19 is a deceptive disease that appears as a form of deadly pneumonia, but actually causes multiple organ failure. As a matter of fact, many of the patients dying of COVID-19 are not dying of pneumonia. They are having their pneumonia symptoms managed well, they’re intubated, they’re receiving supplemental oxygen, and then, all of a sudden, they go into cardiac arrest from myocarditis.

Information from an Intensivist (ICU doctor) front line Seattle (2020-03-11) [https://www.facebook.com/christin.giordano/posts/10102331587456851]

This means that in order to get at the anatomy of the disease, a lot of extra work must be done to collect heart, brain, kidney, and liver tissues (not just the lungs) and examine them for possible pathological changes. It also means that doctors and nurses need droplet and aerosol protection; you can’t let the virus into your mucous membranes or breathe it. You have to keep it out of the eyes, nose, and mouth.

Furthermore, it means that patients need treatment that takes into account all of these other organs as well. Healthcare workers should wear P100 or CBRN full-face respirators (or a loose-fitting full-head hood unit with a PAPR), Tyvek overalls, and gloves, they need to treat each patient as a major aerosol or droplet hazard, and they have to treat their feces and urine as hazardous, and they must thoroughly disinfect patients’ rooms to prepare them for other patients.

This is not what is happening. Doctors are going out there with aprons, surgical masks or rarely N95s that are in short supply, and perhaps a face shield and a hair net. They are overwhelmed, and the environmental services in hospitals are also overwhelmed, trying to keep patients’ rooms clean.

This is an unimaginable tragedy. Our healthcare workers are going to get sick at this rate. It is inevitable.

SECTION VI: Glossary

COVID-19 stands for Coronavirus Disease of 2019, so named because the first cases occurred in 2019:

Coronavirus disease 2019 [https://en.wikipedia.org/wiki/Coronavirus_disease_2019]

2019–20 coronavirus pandemic [https://en.wikipedia.org/wiki/2019–20_coronavirus_pandemic]

The name COVID-19 was specifically chosen to avoid location naming, stigmatization, or any associations with the 2003 SARS outbreak:

WHO Names Disease Caused by New Coronavirus: COVID-19 [https://globalbiodefense.com/2020/02/11/who-names-disease-caused-by-new-coronavirus-covid-19/]

In fact, the WHO has avoided using SARS-CoV-2, the taxonomic name for the virus, in their official literature:

New coronavirus puts focus on the science of naming new viruses [https://www.scienceboard.net/index.aspx?sec=sup&sub=can&pag=dis&ItemID=537]

ID Blog: SARS-CoV-2 – What’s in a name? [https://www.mdedge.com/infectiousdisease/article/217863/coronavirus-updates/id-blog-sars-cov-2-whats-name]

The causative agent of COVID-19 is SARS-CoV-2, a betacoronavirus and close relative of SARS-CoV and MERS-CoV, the causative agents of SARS and MERS, respectively:

Severe acute respiratory syndrome coronavirus [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus]

Middle East respiratory syndrome [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome]

Severe acute respiratory syndrome coronavirus 2 [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2]

These viruses belong to a family of bat coronaviruses, the natural reservoirs of which are, of course, bats:

Bats and Coronaviruses [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356540/]

The specific term for this type of virus is a betacoronavirus, a genus of coronavirus, so named for their “halo” of spike proteins which resembles the Sun’s corona:

Betacoronavirus [https://en.wikipedia.org/wiki/Betacoronavirus]

Coronavirus [https://en.wikipedia.org/wiki/Coronavirus]

Furin is a protein that cuts proteins to activate them:

Furin [https://en.wikipedia.org/wiki/Furin]

SARS stands for Severe Acute Respiratory Syndrome and the reason why the virus is referred to by this name is because it causes a condition known as ARDS, Acute Respiratory Distress Syndrome:

Acute respiratory distress syndrome [https://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome]

This ARDS is the end-stage of the viral pneumonia the disease causes, which is so severe that the inflammation can almost completely disable the lungs.

Myocarditis is the term for inflammation of the heart muscle, which can have numerous potential causes, including infection of the heart:

Myocarditis [https://en.wikipedia.org/wiki/Myocarditis]

Myoglobinemia is a condition caused by excess myoglobin in the blood, such as from the breakdown of muscle tissue. See also, rhabdomyolysis:

Rhabdomyolysis [https://en.wikipedia.org/wiki/Rhabdomyolysis]

Hepatitis is inflammation of the liver:

Hepatitis [https://en.wikipedia.org/wiki/Hepatitis]

Acute Kidney Injury is the term for conditions that directly insult the kidneys, such as sepsis or myoglobinemia:

Acute kidney injury [https://en.wikipedia.org/wiki/Acute_kidney_injury]

The Medulla is part of the brain stem, and governs many basic autonomic functions of the body:

Medulla oblongata [https://en.wikipedia.org/wiki/Medulla_oblongata]

Cerebrovascular disease refers to diseases of the blood vessels of the brain:

Cerebrovascular disease [https://en.wikipedia.org/wiki/Cerebrovascular_disease]

ACE2 stands for Angiotensin Converting Enzyme 2, an enzyme that converts Angiotensin II into Angiotensin 1-7:

Angiotensin-converting enzyme 2 [https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme_2]

ACE2 angiotensin I converting enzyme 2 [https://www.ncbi.nlm.nih.gov/gene/59272]

Angiotensin II is a vasoconstrictive hormone:

Angiotensin II [https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_II]

COMPOUND SUMMARY - Angiotensin II [https://pubchem.ncbi.nlm.nih.gov/compound/Angiotensin-II]

Angiotensin Converting Enzyme 2 and Angiotensin II are both part of the Renin-Angiotensin-Aldosterone System, or RAAS:

Renin–angiotensin system [https://en.wikipedia.org/wiki/Renin–angiotensin_system]
 
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heathercho

常識を変えたら驚きが日常に
True & Honest Fan
kiwifarms.net
10/10 on the effort post, but there are a lot of microbiologists and virologists etc out there who don't think this is as serious as all that. Strange how the media has been very unwilling to listen to them when they'd usually consult them.

@Drain Todger, I'm sorry but I just find it exceptionally odd that you signed up when this Corona shit broke and all you've been doing is fear mongering.
Which is fine, that's your take, but it's literally all you've done and is rather odd.
 

Drain Todger

Unhinged Doomsayer
True & Honest Fan
kiwifarms.net
10/10 on the effort post, but there are a lot of microbiologists and virologists etc out there who don't think this is as serious as all that. Strange how the media has been very unwilling to listen to them when they'd usually consult them.

@Drain Todger, I'm sorry but I just find it exceptionally odd that you signed up when this Corona shit broke and all you've been doing is fear mongering.
Which is fine, that's your take, but it's literally all you've done and is rather odd.

Well, the thing is, many of these complications are rare, thankfully. This virus will be mild for a majority of people, but for many people, it won't be.

I figured it would be a good idea to stay on top of the scientific literature and figure out exactly what this virus can do to the human body. Unraveling the pathology took over a hundred hours of cross-referencing everything in great detail, including much of the leaked footage:



I was very concerned by the footage that I saw of people collapsing and then going rigid from head to toe with decorticate/decerebrate posturing, because that's a clear neurological sign. If someone goes down with just a heart attack or something along those lines, they will show variations in posture. They'll clutch their chest, bend their knees, struggle, etc. But nope, these people were going down and going rigid, legs extended out straight.

So, I wanted to see if there was evidence to support neurotropism of SARS-CoV-2. There is. There is a lot of evidence to support that conclusion. See Section II-E, above.


neurotropic
adjective
neu·ro·trop·ic | \ ˌn(y)u̇r-ə-ˈträp-ik \
Medical Definition of neurotropic

: having an affinity for or localizing selectively in nerve tissue
neurotropic stains, neurotropic viruses— compare DERMOTROPIC, PANTROPIC
 

heathercho

常識を変えたら驚きが日常に
True & Honest Fan
kiwifarms.net
Well, the thing is, many of these complications are rare, thankfully. This virus will be mild for a majority of people, but for many people, it won't be.

I figured it would be a good idea to stay on top of the scientific literature and figure out exactly what this virus can do to the human body. Unraveling the pathology took over a hundred hours of cross-referencing everything in great detail, including much of the leaked footage:



I was very concerned by the footage that I saw of people collapsing and then going rigid from head to toe with decorticate/decerebrate posturing, because that's a clear neurological sign. If someone goes down with just a heart attack or something along those lines, they will show variations in posture. They'll clutch their chest, bend their knees, struggle, etc. But nope, these people were going down and going rigid, legs extended out straight.

So, I wanted to see if there was evidence to support neurotropism of SARS-CoV-2. There is. There is a lot of evidence to support that conclusion. See Section II-E, above.


Most of those videos were unrelated to corona or fake videos though. That's the major issue. There is no evidence they're corona related at all. In fact, at least 2 of the videos I've seen are known viral videos from asia. They're jumpscare type videos.

Corona Virus, as a whole, is a known virus. This isn't a new thing that people don't know anything about. They know how it works. Viral Encephalitis or neuronal degeneration - which it can cause in rare cases, wouldn't cause what half those videos shows.

I mean, only just recently have ""scientists"" been willing to admit that something like glandular fever can cause CFS, neurological issues etc.
It happens with viruses. But the decorticate/decerebrate posturing? If a few of the videos are fake, then honestly I don't trust any of them.
 
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Drain Todger

Unhinged Doomsayer
True & Honest Fan
kiwifarms.net
Most of those videos were unrelated to corona or fake videos thought. That's the major issue. There is no evidence they're corona related at all. In fact, at least 2 of the videos I've seen are known viral videos from asia. They're jumpscare type videos.

Corona Virus, as a whole, is a known virus. This isn't a new thing that people don't know anything about. They know how it works. Viral Encephalitis or neuronal degeneration - which it can cause in rare cases, wouldn't cause what half those videos shows.

I mean, only just recently have ""scientists"" been willing to admit that something like glandular fever can cause CFS, neurological issues etc.
It happens with viruses. But the decorticate/decerebrate posturing? If a few of the videos are fake, then honestly I don't trust any of them.

A few videos are indeed fake. That one with all the kids in the high school gymnasium shaking on the ground or whatever? Totally unrelated. However, a majority of these vids of people collapsing seem to be real and related to COVID-19, not just people having ordinary seizures.

Many survivors of SARS had lung fibrosis, chronic fatigue, mental abnormalities, and so on. Also, the virus was found in the brains of victims of the first outbreak.

There is also a recent report that the virus has been found in a patient's cerebrospinal fluid in China, which is a fairly conclusive indication of neurotropism. Many of the critical patients have been reported as being incapable of breathing on their own without a ventilator. This virus is suspected to be capable of climbing the parasympathetic nerves of the lungs, into the vagus nerve, and into the cardiorespiratory center of the medulla. In other words, it can cause dysautonomia.


The way the virus causes damage to tissue is primarily by provoking an autoimmune reaction. Normally, Angiotensin II is taken up by ACE2 receptors, which catalyze its conversion to Angiotensin 1-7. From there, it acts as a Mitochondrial assembly receptor agonist. The virus inhibits this process by using up ACE2 receptors as its entry receptor. In the process, this normal cycle of Ang II > Ang 1-7 > MasR is interrupted, the excess Ang II builds up and causes inflammation and hypertension by activating AT1R, a metric fuckload of inflammatory cytokines race to the site and cause tissue damage, and blammo. Organ failure.



It's worth mentioning that SARS does the exact same thing, with the exact same receptor. The reason why this thing is spreading so fast is because of the parts that are 20% genetically different from SARS-CoV. The S protein has furin cleavage sites that make it extremely infectious and efficient at endocytosis. In other words, SARS-CoV-2 has an HIV-like method of directly fusing to human cells. It doesn't take very much of it to infect someone. The syndrome it causes is otherwise very SARS-like, except the efficient S protein might also perhaps mean that the virus is very invasive and can stealthily reach deeper into certain tissues before the immune system starts rejecting it. It's not just more infectious, but also potentially more bioactive (i.e. the furin cleavage sites do not only facilitate human-to-human transmission, but also proliferation of the virus within an organism). That part requires further study, however.
 
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ADHD

セックスキッテン
Local Moderator
True & Honest Fan
kiwifarms.net
@Drain Todger the Microsoft Word document with this information that you linked a couple times in the megathread has the name David Jamison in the author section of the details tab. Are you this David Jamison? If you have actual credentials, you may as well get verified.

EDIT: I was right about the name, wrong about the LinkedIn profile.
 
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Zero Day Defense

"Now come, Samurai. Put on a good show."
kiwifarms.net
and yet it's still racist to say "Fuck the Chinese"

With 650 billion million women (less, accounting for adult age)?

The spirit is willing but the flesh will be spongy and exhausted.

EDIT: What the frick-- I was about to sex up more humans than there are on planet Earth.
 
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Fareal

will definitely consider what you have said
True & Honest Fan
kiwifarms.net
SARS stands for Severe Acute Respiratory Syndrome and the reason why the virus is referred to by this name is because it causes a condition known as ARDS, Acute Respiratory Distress Syndrome:

if it was caused by a retrovirus would we call it ret.ARDS
 

ADHD

セックスキッテン
Local Moderator
True & Honest Fan
kiwifarms.net
I thought he claimed to be a light rail mechanic/operator in Seattle or something like that? Just enthuisiastic amateur not a biomedical engineer.
Well he claimed this work was "his" file.
I’ve updated my COVID-19 file with a bunch more information, with info on PPE and a Glossary:


This is getting a little scary, folks.



The nose cells controlling smell are nerves. The virus has been found in people’s cerebrospinal fluid. If people are saying it’s not neurological at this point, they’re being disingenuous. :cryblood:
Archive of result the tinyurl link.

So either he is David Jamison or he is trying to pass off David Jamison's work as his.

I don't care either way. My only point was if he wanted people to take him seriously and not as a doomposter, he might as well get verified.

EDIT: It's his work.
 
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Forever Sunrise

Avatar? I don't need no stinkin' avatar.
kiwifarms.net
Gotta love the 'if it's only going to cause some people to die in horrific fashion, why fear-monger? It's not like it's everyone' rationale being used every single time somebody highlights how dangerous this thing is.

It's okay guys, HIV doesn't always transit during buttsex. Why persecute pozzers if you can't be sure they'll infect people they have sex with? If it's not a 100% chance, shut the fuck up. There are bigger issues to whine about!
 

Save the Loli

kiwifarms.net
Just because a disease can trigger shit like this (which I believe this disease can) doesn't mean it will trigger this. This seems mostly like rare complications.

And remember if there are two strains of COVID-19 (as seems the case), whichever one is more effective at spreading will outcompete the other. That means less debilitating symptoms for the carrier and as with syphilis, smallpox, various influenza strains, and many other diseases (probably including other human coronaviruses which are now the common cold, coronavirus epidemics must've happened in the past yet with a mortality rate like we're seeing with COVID-19 they would barely register prior to the 20th century), will evolve into irrelevence.
 

The Gag Knuckle

kiwifarms.net
A few videos are indeed fake. That one with all the kids in the high school gymnasium shaking on the ground or whatever? Totally unrelated.

looool

"guys, I might have knowingly and deliberately posted false information, but I assure you everything else is legit! Please be nice to me, I spent a whole ten hours typing "COVID" into my school's research portal"
 

Drain Todger

Unhinged Doomsayer
True & Honest Fan
kiwifarms.net
Well he claimed this work was "his" file.

Archive of result the tinyurl link.

So either he is David Jamison or he is trying to pass off David Jamison's work as his.

I don't care either way. My only point was if he wanted people to take him seriously and not as a doomposter, he might as well get verified.

My name is David Jamison. I am not that David Jamison, however. He has a doctorate. I do not.
 

Drain Todger

Unhinged Doomsayer
True & Honest Fan
kiwifarms.net
NGL, I'm getting really tired of your doomer shit, dude. It literally helps no one.

Doomer shit? All the scientific papers supporting my conclusions are right there. Read them, and learn. Or don't. See if I care.

I've been back and forth with PhD biologists, virologists, and immunologists over this, and we all agree that the official accounts of what this virus can do to the human body are lacking in a whole lot of information.

The CDC's own published guidelines present this disease, essentially, as a form of severe pneumonia. They don't mention any of the neurological consequences.


Go on. Hit Control-F. Tell me if you can find the word neurological in any of that. Sure, the cardiac issues and acute kidney injury, that part is known. But the neurotropism? Not particularly well-known.

However, the virus is making people drop on the ground, flop like a fish, extend their legs like drowning victims, and suffer decorticate/decerebrate posturing:




I have an entire section up there that confirms that SARS-CoV-2 can have profound neurotropism:

Section II-E: Neurological Signs

SARS-CoV (a relative of SARS-CoV-2) has been shown to cause neural death (surprisingly without encephalitis) in transgenic mouse models.
Recent, concerning reports of anosmia in COVID-19 patients may perhaps indicate olfactory nerve infiltration or inflammation of the surrounding tissues; this needs investigation:

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 (2008-05-21) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493326/]

If you've lost your sense of smell or taste, you could be a 'hidden carrier' of the coronavirus (2020-03-22) [https://www.businessinsider.com/coronavirus-symptoms-loss-of-smell-taste-covid-19-anosmia-hyposmia-2020-3]

SARS-CoV was also found in the brains of infected patients in previous outbreaks:

New Study Shows SARS Can Infect Brain Tissue (2005-09-15) [https://www.sciencedaily.com/releases/2005/09/050915002938.htm]

Neurological manifestations in severe acute respiratory syndrome. (2005-10-29) [https://www.ncbi.nlm.nih.gov/pubmed/16252612]

Angiotensin converting enzyme 2 in the brain (2009-04-12) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667944/

Recent information seems to suggest that SARS-CoV-2 can cause neurological symptoms and cerebrovascular disease, leading to loss of autonomic functions of the brain and, in the worst case, lingering brain damage. The virus can apparently attack the medulla or even cause viral encephalitis, and some patients have had the virus found in their cerebrospinal fluid:

The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients (2020-02-24) [https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25728]

Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study (2020-02-25) [https://www.medrxiv.org/content/10.1101/2020.02.22.20026500v1]

Beijing hospital confirms nervous system infections by novel coronavirus (2020-03-05) [http://www.xinhuanet.com/english/2020-03/05/c_138846529.htm]

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms (2020-03-13) [https://pubs.acs.org/doi/10.1021/acschemneuro.0c00122]
https://pubs.acs.org/doi/10.1021/acschemneuro.0c00122
 
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